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INDEX OF DRUGS camila. 30 CAMPATH . 15 CAMPRAL . 11 CAMPTOSAR . 15 CANASA . 35 captopril . 23 captopril hydrochlorothiade. 23 CARAC. 27 CARAFATE ORAL LIQUID. 29 carbamazepine. 9 CARBATROL . 9 carbidopa levodopa . 17 carbidopa levodopa er. 17 carboplatin. 15 Cardiovascular Agents . 2, 22 CARIMUNE . 33 carisoprodol. 39 carteolol hcl. 36 cartia xt. 23 carvediol. 23 CASODEX. 33 CEENU . 15 cefaclor. 7 cefadroxil . 7 cefazolin sodium . 7 cefdinir . 7 cefotaxime sodium . 7 cefotetan injection. 7 cefoxitin sodium. 7 CEFTIN LIQUID. 7 ceftriaxone. 8 cefuroxime axetil . 8 cefuroxime sodium. 8 CELEBREX. 6 CELLCEPT. 33 CELONTIN. 9 Central Nervous System Agents . 26 cephalexin . 8 CEREDASE. 28 CEREZYME . 28 cesia. 30 CHANTIX. 11 chloroquine phosphate . 17 chlorpromazine . 18 chlorthalidone . 23 chlorzoxazone . 39 cholestyramine . 23 cholestyramine light. 23 chorionic gonadotropin . 30 ciclopirox lotion . 12 ciclopirox nail lacquer. 12 ciclopirox olamine cream. 12 cilostazol . 22 CILOXAN. 8 cimetidine. 29 CIPRO INJECTION, ORAL LIQUID. 8 ciprofloxacin . 8 CISPLATIN . 15 citalopram . 11 cladribine. 15 claravis . 27 clarithromycin . 8 clemastine fumarate 2.68mg tablets. 37 clemastine fumarate syrup . 37 CLEOCIN CAPSULES 75mg . 8 CLEOCIN PEDIATRIC GRANULE . 8 CLEOCIN VAGINAL OVULES . 8 CLIMARA . 31 CLIMARA PRO . 31 clindamycin calsules . 8 clindamycin phosphate topical. 8 CLINIMIX DEXTROSE 5 . 39 clobetasol propionate . 27 clobetasol propionate e . 27 clomipramine . 11 clonidine. 23 clotrimazole cream, lozenge . 12 clotrimazole betamethasone. 27 clozapine . 18 COGENTIN INJECTION. 17 colchicine . 13 colchicine injection . 13 colestipol . 23 COLOCORT . 35 COMBIVENT. 37 COMBIVIR. 19 COMPRO. 12 COMTAN . 17 COMVAX. 33 constulose. 29 COPAXONE. 33 COREG . 23 Page | 43. Nevada Medicaid Pharmacy & Therapeutics Committee Location of Meeting 401 South Carson Street, Room 2135, Carson City, NV Teleconference 555 E. Washington, Room 4406 Las Vegas, NV MEETING MINUTES OF July 14, 2004, and August 12, 2004 July 14, 2004, 12 Noon Committee Members Carson City: Steven Phillips, MD, Chairman Linda Flynn, RPh Alan Greenberg, MD Carl Heard, MD Larry Pinson, PharmD Susan Pintar, MD Thomas Wiser, PharmD -Late Absent: Judy Britt, PharmD Others Present: Carson City: Darrell Faircloth AGO, Coleen Lawrence DHFCP, Nancy Davis DHCFP, Jeff Monaghan PharmD First Health Services Corporation, Dawn Daly RPh First Health Services Corporation, Charles Duarte DHCFP, Joann Phillips, Bob McElderry Purdue, Bert Jones GSK , Jeanette Belz NV Psych Assn, Claude Lardinois MD, Myan Hawkins NDACA, Rachel Brooks, Jim Morgan Novartis, Tracy Davies Lilly, John Ostezan Lilly, Steve Schaerrer AZ, Tina Lin Shire, Bill Finnerery Shire, Pat Chimei NAMI, Bucnhi Tyler NAMI, Mark Burshell NAMI, Rod Muir P&G, Chris Lepore J&J, Slate Sparks Bertek, Tom Wood Wyeth, Scott Cullins Wyeth, Danielle Walters Sanofi, Kara Smith BIPI, Joe Duarte Cephalon, Barbara Colgin Ortho, Khollin Takedo, Jesse Deaver Aventis, Roland Baldwin Wyeth Las Vegas: Jamie Wyels RPh First Health Services, Paul Pereira TAP, Sedrick Spencer Roche, Patty Craddock NDA, Patty Miller DHCFP, Sherri Serrano Lilly, Chris Jensen Lilly, Kristin Kight Lilly. I. Call to Order and Roll Call Chairman Steven Phillips called the meeting to order at 1pm. Committee members present in Las Vegas: Diana Bond, RPh, Robert Horne, MD; Carson City: Linda Flynn, RPh, Alan Greenberg MD, Thomas Wiser, PharmD. Late ; Steven Phillips, MD, Carl Heard, MD, Larry Pinson, PharmD, and Susan Pintar, MD. II. Approval of Minutes of June 17th, 2004 Meeting Motion to Accept minutes: Dr. Pinson Seconded: Ms. Flynn Ayes: Unanimous Dr. Horne & Dr. Wiser not present to vote ; Motion Carried Committee Members in Las Vegas: Diana Bond, RPh Robert Horne, MD. There are not that many cardiac clinics around. Hawki does NOT work for one in this area. If he did, he would be aware of those who have a pretty decent active life with an EF of less than 20, even 12 or 15. Yes, it's very low, Yes it can be corrected with one or a combination of about 10 solutions. Going back to the base of this portion of the thread. Exercise is paramount. Mental attitude or belief determines whether the exercise is done AND its effectiveness. Beta lockers are almost always used. Often the doctor knows that the Beta blocker is not highly effective in a particular patient very rare ; , but the doctor still presents a very positive incentive to the patient. Now the trolls will say that Corwg is not a placebo. It isn't normally, but what is Cireg to a non physically responder? GEE GOSH medicine can be complicated unless you're a scrub and have to remember to use the right gloves. I recently made a survey where a P.A Nurse with rights to prescribe ; 8 out 0f 10 prescriptions were in error in one area or another. One of them involved higher math. The doctor wrote in notes, 1 tablet a day for 30 days. The quantity in the prescription was 90. Section 1 HIGHLIGHTS OF 1998 PROGRAM CHANGES The following discusses the major changes in Medi-Cal and related programs during Calendar Year 1998. Statewide Outreach and Education Campaign, February 1998 The Department of Health Services launched a statewide outreach and education campaign to help families learn about and apply for new health programs for children. Expansion of Children's Programs, March 1998 Pursuant to state law SB 903 and AB 217 ; , effective March 1, 1998, Medi-Cal made two changes to the Percent Programs. First, Medi-Cal began disregarding resources of children in the Percent Programs. Second, Medi-cal adopted the new federal option to allow children up to 19 covered immediately under the 100 Percent Program without having to wait for the mandatory phase in period to expire. That provision required that children had to be born after September 30, 1983 to be covered ; . Napa County, March 1998 Napa county became a county organized health system COHS ; in March 1998, and the Solano COHS processes their claims. New Drug Added to the contract List of Drugs, June 1998 Corsg was added effective June 1, 1998. Corsg is a new drug for the treatment of heart failure. Health Families Program, July 1, 1998 The Healthy Families Program was implemented with the passage of Assembly Bills 217, 1126, 1572 and Senate Bill 903. A joint main-in application for pregnant women and children was made available through select community-based programs, county welfare departments and the Healthy Families program enrollment contractor. EPSDT In-Home Nursing Rates, July 1998 Legislative action required the Department, beginning July 1, 1998 to increase the EPSDT In-Home Nursing Services reimbursement rates. These services are provided by in-home nursing providers. Rezulin Troglitazone ; Added to List of contract Drugs, July 1998 Rezulin was a new drug added for the treatment of diabetes.

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KEY PHARMACEUTICAL GROWTH DRIVERS GSK's number one product, Seretide Advair, for the treatment of asthma and Chronic Obstructive Pulmonary Disease COPD ; continues to grow strongly with sales up 22% to 581 million. In the USA, sales rose 24% to 317 million. European and International sales were both up 18%. The growth prospects for Advair were further strengthened with the US launch in the quarter of a new indication for COPD and with FDA approval for the treatment of asthma in children above 4 years. GSK also filed Seretide for approval in the treatment of asthma in Japan on 16th April. The Avandia family of diabetes treatments Avandia and Avandamet ; performed well with sales growing 18% to 238 million. Reported US sales growth of 11% was adversely impacted by wholesaler stocking patterns and underlying growth is estimated to be approximately 28%. Sales have benefited from the recent launch of a higher strength Avandamet formulation. European sales were up 83% to 22 million supported by an increased awareness of Avandia's benefits. In addition Avandamet was approved in the EU in December 2003 and rollout of this new product has just begun. International sales grew 43% to 31 million. The exceptionally strong growth of Lamictal continues, with sales up 29% to 153 million. In the USA, Lamictal sales rose 39% to 91 million. US sales have benefited from Lamictal's new indication to treat bi-polar disorder. Sales of Coreg, for the treatment of heart failure, grew by 27% to 94 million. Growth prospects for the product were strengthened by data from the landmark COMET study which has recently been included in promotional materials. This showed that Corsg reduced risks of death from a cardiovascular event by 20%, a heart attack by 30% and death from a stroke by 67% compared to Metoprolol. On 13th April, GSK announced that it would acquire Sanofi-Synthelabo's injectable anti-thrombotic agents Fraxiparine and Arixtra, conditional on Sanofi successfully completing its acquisition of Aventis. These products would complement GSK's cardiovascular business. Valtrex for genital herpes ; sales rose 31% to 133 million driven by a strong performance in the USA sales up 38% to 86 million ; . Valtrex is the only treatment with an indication to reduce transmission of genital herpes, supporting the strong efficacy profile of the product and its use in once-daily therapy. Sales of GSK's HIV products were 348 million. Growth in Europe + 9% ; and International markets + 12% ; was offset by lower sales in the USA -8% ; . However reported US growth was impacted by stocking patterns in the first quarter 2003; underlying percentage growth for the US franchise is estimated to be in the low single digits. Demand for Levitra continued to build in the quarter. Estimated total sales for the product were around 44 million compared with 23 million in Q4 2003 ; , giving a contribution to GSK's turnover of 17 million. Total prescriptions in the United States increased by 34% in Q1 2004 compared to Q4 2003. NEW LINE EXTENSIONS MITIGATE GENERIC COMPETITION Paxil CR performed very well in the quarter, with sales of 101 million + 37% ; . CR has maintained its market share in the US anti-depressant market since the launch of generic Paxil and was recently launched for the treatment of social anxiety disorder. Total sales of Seroxat Paxil fell 36% to 291 million, with US sales down 48% due to the continuing impact of the launch of generic versions of Paxil IR in September 2003. Wellbutrin sales rose 17% to 221 million, driven by the continued strong uptake of Wellbutrin XL which now represents 44% of total branded and generic Wellbutrin SR + XL ; prescriptions. Generic competition to the most frequently prescribed dosage form of Wellbutrin SR 150 mg ; began in late March. This had a limited impact on reported sales for the quarter, but will adversely affect future quarters and cozaar. Msgranny springcom jon's january 30 reply to mary's january 30, 2000 - hi mary, there's a page full of information about coreg here. The program makes use of PERL's rich pattern recognition resources to search for character strings of the form [Drosophila melanogaster]. We want to specify the following pattern: a square bracket, followed by a word beginning with an upper case letter followed by a variable number of lower case letters, then a space between words, then a word all in lower case letters, then a closing square bracket and crestor.

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The Department considered this suggestion and decided to proceed with the recommendations of the Department's P&T Committee and medical specialist consultants. Those recommendations focused on mild to severe heart failure or post myocardial infarction with lelft ventricular ejection fraction 40% and history of therapeutic failure of Coreg immediate release. Treatment produces few immediate benefits while incurring important risks. There are also concerns that treatment is difficult and requires special expertise, and that patients starting the drugs may experience hypotension, retention of sodium, and possibly worsening HF during the first few weeks of therapy. Many physicians assume that the benefits of therapy are delayed, so that a favorable effect on symptoms, hospitalizations, and death may not become apparent for months. Studies have suggested that initiation of therapy is well tolerated in patients with mild HF, but is associated with an early increase in risk of worsening HF leading to withdrawal of the drugs in patients with severe HF. This study evaluated the early effects of the beta-blocker carvedilol Coreg ; in patients with severe HF. Conclusion: In clinically euvolemic individuals with severe HF, the benefit of beta-blocker therapy was similar to that seen during long-term therapy and diovan. 1. African values: Historically, African communities had well articulated caring structure that preserved the quality of life for older persons but this was linked to the low chance of the survival of large numbers of older persons. The situation is changing, albeit, gradually: early mortality no longer limits the number of surviving elderly and traditional respect and caring structures are now under substantial social challenge Habte-Gabr, 1987; El-Badry, 1988; Adamchak, 1989; AGES, 1995; Vatuk, 1996 ; . The literature on informal support systems characteristic of the African model, frequently give forewarning on the weakening of African traditional family structures. Much of the literature cite modern nuclear family's inability to continue its care giving roles in the context of current monetized urbanizational life as women increasingly join the labour force. The impact of world economic trends on family living standard is likewise projected as paving the way for extended family exclusivity. Mosamba, 1984; Shuman, 1991; Apt, 1992; 1996 ; . The family's capacity to cushion older members essentially depends on three variables: its social and economic situation; whether it falls within the ambit of a social security system and the actual nature and structure of the family Chawla, 1996 ; . When elderly Nigerians were asked "What sorts of things give the most status to-day Ekpenong, Oyeneye, Peil, 1987: 16-17 ; , the general agreement was that money, character and education in that order ; are most important. Only a few respondents mentioned the traditionally accepted norm, namely, children and family. The majority of Nigerian elders are said to be pessimistic about modern circumstances in Nigeria and about the present and future situation of older persons. In the final analysis, the conclusion drawn by the authors was that even though elderly Nigerians continue their traditional roles, these roles are now less important in an increasingly materialistic society. Elderly Temne of Sierra Leone, also in West Africa, summarize it all in their reflective assessment of themselves as "a short changed generation" Dorjhan, 189: 272-275 ; . In this reflection they meant that they had "paid their dues" when they were young but their turn for the pay off was begrudged by social change Dorjhan, ibid ; . Of the Samia of Kenya in East Africa, Cattell 1989: 233 ; observes that elderly Samians influence has been "devalued, displaced, replaced and a significant basis of their respect has been eroded". Many elderly Samians identified education as the crucial element in this change and emphasized that it has reduced respect for them, the support and care given them and the seeking of advice from them. Now one. The Revised National Tuberculosis Control Program A comprehensive review of the tuberculosis program in India in 1992 found that less than half of patients with tuberculosis received an accurate diagnosis and that less than half of those were effectively treated. Laboratory services were underutilized, treatment regimens were unnecessarily complicated, drug shortages were common, and completion of treatment was not systematically assessed. In response, a pilot project using the World Health Organization WHO ; recommended strategy of directly observed treatment, short-course DOTS ; , 7 the Revised National Tuberculosis Control Program, was begun in 1993. Diagnosis is primarily by sputum microscopy, treatment is directly observed, and standardized regimens and methods of recording and reporting are used. For diagnosis, physicians are trained to ask all patients attending health care facilities if they have had a cough for three weeks or more. Those with a cough undergo three sputum-smear examinations over a two-day period. If two or three of the smears are positive for acidfast bacilli, antituberculosis treatment is initiated. If all three smears are negative, one to two weeks of broad-spectrum antibiotics e.g., trimethoprimsulfamethoxazole ; are prescribed. If only one of the three smears is positive or if symptoms persist after the administration of broad-spectrum antibiotics, a chest radiograph is obtained, usually at a larger health center, and the patient is evaluated. On the basis of their clinical features Table 1 ; , patients are given one of three categories of treatment, and treatment is based on the category to which a patient belongs. All treatment is given three times weekly Table 2 ; . Patients who have not previously been treated who have new sputum smears positive for acid-fast and hytrin. Indications Based on a review of this drug by the National Academy of Sciences-National Research Council and or other information, FDA has classified the indications as follows: Effective: For the management of manifestations of psychotic disorders. Probably effective: For control of involutional melancholia or of the manifestations of manic-depressive illness manic phase ; .For the control of moderate to severe agitation. hyperactivity or aggressiveness in disturbed children. Possibly effective: For control of excessive anxiety, tension and agitation as seen in neuroses. Final classification of the less-than-effective indications requires further investigation, Contraindications: Comatose states, presence of large amounts of C.N.S. depressants, or bone marrow depression. Warnings: Avoid using in patients hypersensitive e.g. blood dyscrasias, jaundice ; to any phenothiazine. Caution patients about activities requiring alertness e.g. operating vehicles or machinery ; especially during the first few. Global pharmaceutical turnover in the fourth quarter of 2004 increased three per cent, reflecting a US turnover increase of four per cent to 2, 114 million; whereas in Europe turnover grew two per cent to 1, 397 million, and in International turnover grew five per cent to 976 million. Turnover in the USA was impacted by generic competition for Wellbutrin and Paxil. Excluding sales of these products, turnover grew 10 per cent in the USA. Pharmaceutical turnover by therapeutic area GlaxoSmithKline's ability to continue to deliver pharmaceutical turnover growth, despite generic competition to several of its products, is primarily due to an exceptionally broad product portfolio of fast-growing, high-value products. These include the respiratory product Seretide Advair, up 19 per cent 2.5 billion ; , the diabetes treatment Avandia Avandamet, up 32 per cent 1.1 billion ; , Lamictal for epilepsy bipolar disorder, up 32 per cent 0.7 billion ; , Valtrex for herpes 0.6 billion ; , up 24 per cent, Coreg for heart disease, up 34 per cent 0.4 billion ; and vaccines, up 11 per cent 1.2 billion ; . In all, 12 GlaxoSmithKline products each had sales of over 500 million in 2004. Respiratory GlaxoSmithKline continues to be the global leader in respiratory pharmaceuticals with sales of its three key products, Seretide Advair, Flixotide Flovent and Serevent, amounting to 3.4 billion, up nine per cent. Sales of Seretide Advair, the Group's largest product grew 19 per cent to 2.5 billion although this contributed to declines in Serevent and Flixotide, its constituent products. In the USA, Advair sales grew 20 per cent to 1.3 billion. Growth of Seretide in Europe was also strong up 18 per cent to 902 million ; , although reported growth in the fourth quarter was adversely impacted by a one-off rebate adjustment in Germany and wholesaler de-stocking in Italy. International sales grew 15 per cent, reflecting good growth in all geographic areas. The older respiratory products Ventolin and Becotide continued to decline as patients converted to newer products. Central nervous system CNS ; CNS sales declined 16 per cent to 3.5 billion. Sales declined in all regions. Total sales of the Paxil franchise were down 39 per cent to 1.1 billion as a result of generic competition to Paxil IR, sales of which declined 53 per cent to 667 million. Mitigating this decline was the strong performance of the product in Japan, up 25 per cent to 171 million and the performance of Paxil CR which generated sales of 396 million, up 14 per cent. Total sales of Wellbutrin products fell 12 per cent to 751 million. Wellbutrin IR and SR sales fell 64 per cent to 284 million as a result of generic competition. This impact was partially offset, however, by the exceptionally strong performance of Wellbutrin XL, the new once-daily product, which achieved sales of 467 million in its first full year on the market. The strong growth of GlaxoSmithKline's epilepsy and bi-polar disorder treatment Lamictal continues, with sales up 32 per cent to 678 million. Ongoing US growth, up 49 per cent to 414 million, is being driven by the indication for the maintenance treatment of bi-polar disorder received last year. Anti-virals Global HIV product sales rose four per cent to 1.5 billion and sales in the USA increased four per cent to 747 million. GlaxoSmithKline continues to grow its HIV franchise, despite the launch of several new products by competitors. HIV performance was enhanced by the launch of Epzicom, a new combination product Epivir Ziagen ; in the USA in August 2004 and in the EU under the name Kivexa ; in January 2005. Sales of the herpes treatment Valtrex exceeded 500 million for the first time in 2004 up 24 per cent to 571 million ; . Performance is being driven by the USA up 30 per cent to 369 million ; where the product is the clear market leader in treatments for genital herpes. Anti-bacterials Anti-bacterial sales declined nine per cent worldwide and 24 per cent in the USA reflecting generic competition in all regions. Metabolic The diabetes treatments Avandia Avandamet continue to perform very strongly, with overall sales of 1.1 billion up 32 per cent ; . Sales in the USA grew 26 per cent to 852 million. Encouragingly, Avandia Avandamet are also growing very strongly in Europe and International markets with sales up 49 per cent and 62 per cent, respectively. Strong performance in these markets is driven by the growing acceptance amongst opinion leaders and physicians of the benefits of these new products in improving control for diabetic patients. Vaccines The vaccines business had a strong year, with sales up 11 per cent to 1.2 billion. Several key products are driving growth Pediarix Infanrix up 12 per cent to 357 million, Priorix up 14 per cent to 95 million and Fluarix up 38 per cent to 79 million. Oncology and emesis Sales of Zofran grew eight per cent to 763 million, driven by the US performance, up 10 per cent to 565 million. Cardiovascular and urogenital In 2004, Coreg for heart disease ; sales grew 34 per cent to 432 million. Other therapeutic areas Sales of Zantac fell 12 per cent to 273 million with declines in all regions and innopran.

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Flamel Technologies is a world leader in polymerbased drug delivery technology. Flamel's drug delivery platforms, MEDUSA for proteins and peptides and MICROPUMP for small molecules, allow improved therapeutic characteristics, safety profiles and ease of use for a wide variety of drugs. Flamel's expertise ranges from the lab to the production plant. The FDA-approved manufacturing facility in Pessac now comprises over 60, 000 squarefeet. The Pessac facility is the sole manufacturer of microparticles for the GlaxoSmithKline medicine Coreg CR carvedilol phosphate ; extended-release capsules. Flamel is widely recognized for its innovation of delivery systems for small molecule and protein drugs, providing tailored solutions to the biotech and pharmaceutical industries for optimized controlled-release delivery of drugs. Flamel is turning already-marketed or new drugs into more effective and safer medicines for itself and for its partners. The Company is dedicated to working in partnership with established pharmaceutical and biotechnology companies for the development and commercialization of products currently in their pipelines as well as for new products using Flamel's proprietary delivery systems. This model allows Flamel to focus on its core competency of drug delivery, while leveraging the expertise of its partners and atacand.

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Two major gene superfamilies play critical roles in the transport of drugs across plasma and other biological membranes: the SLC and ABC superfamilies. Web sites that have information on these families include : nutrigene.4t humanabc ABC superfamily ; , : bioparadigms slc intro SLC superfamily ; , : pharmaconference slctable SLC superfamily ; , and : TP Search.jp drug transporters ; . Information on pharmacogenetics of these transporters can be found in Chapter 4 and at : pharmgkb and : pharmacogenetics.ucsf . SLC Transporters. The solute carrier SLC ; superfamily includes 43 families and represents approximately 300 genes in the human genome. The nomenclature of the transporters within each family is listed under the Human Genome Organization HUGO ; Nomenclature Committee database at : gene.ucl.ac nomenclature . Table 22 lists the families in the human SLC superfamily and some of the genetic diseases that are associated with members of selected families. The family name provides a description of the function s ; of each family. However, some caution should be exercised in interpretation of family names because individual family members may have vastly different specificities or functional roles. All the SLC families with members in the human genome were reviewed recently Hediger, 2004 ; . In brief, transporters in the SLC superfamily transport diverse ionic and nonionic endogenous compounds and xenobiotics. SLC superfamily transporters may be facilitated transporters or secondary active symporters or antiporters. The first SLC family transporter was cloned in 1987 by expression cloning in Xenopus laevis oocytes Hediger et al., 1987 ; . Since then, many transporters in the SLC superfamily have been cloned and characterized functionally. Predictive models defining important characteristics of substrate binding and knockout mouse models defining the in vivo role of specific transporters and lopid.
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Figure 4.3. Mutant design, from site directed mutagenesis by PCR to insertion to expression vector. Two methods were applied, the first involved pTZ vector before using pQE and the second inserting straight to the pQE30a vector and two different hosts. The correct insert was double checked by sequencing and restriction analysis if available. Legend: RE DNA restriction with appropriate restriction enzymes, M marker, 1 wild type unmutated ; pQE ADI, 2 mutant pQE ADI. Examples of mutagenesis with two phases are shown in figure 4.4. A ; and 4.4. B ; . Controls containing no DNA and single PCR primer with DNA were used. If any bands appeared in the controls the PCR was repeated after replacing contaminated reagents.
Danger signs your symptoms get worse very quickly wheeze or chest tightness or shortness of breath continue after using the reliever medication or return within minutes of taking reliever medication severe shortness of breath, inability to speak comfortably, blueness of lips and lozol and Coreg online. Addition of make resample and make filtazi resample to give the option of filtering in azimuth. As this involves updating master.res differently for every image pair, a separate master.res is now maintained in each individual slave directory. Update to make coreg to be more efficient uses a different strategy for picking which images to coregister ; . Addition of step coreg to allow coregistration for an individual slave image with the master image. Update to make amp dem.m to display the image in matlab instead of using disrg Error in ps load initial.m fixed so that individual PS bperp and look angle values are now correct. Addition of ps load dem.m to allow plotting of PS on shaded relief topography. Other tidying of code. Specific brands and stages include: acebutolol sectral ; stage a ; atenolol tenormin ; stages a, b ; betaxolol kerlone ; stage a ; bisoprolol zebeta ; stages a, c ; cartelol cartrol ; stage a ; carvedilol coreg ; stages a, b, c ; labetalol trandate ; stage a ; metoprolol succinate toprol xl ; stages a, c ; metoprolol tartrate lopressor ; stages a, b ; nadolol corgard ; stage a ; penbutolol levatol ; stage a ; pindolol visken ; stage a ; propranolol inderal ; stages a, b ; timolol blocadren, timolide ; stages a, b ; beta blocker concerns do not abruptly stop taking these drugs and mevacor. Rationale: Availability of other therapy options. Alternatives on the drug list include Premarin estrogens, conjugated ; , Enjuvia estrogens, conjugated, synthetic B ; , estradiol, and estropipate. Rationale: Availability of an "Arated" generic. Alternatives on the drug list include Coreg CR carvedilol extended release ; , atenolol, carvedilol, metoprolol, metoprolol succinate extended release, nadolol, and propranolol. Rationale: Availability of other therapy options. Alternatives on the drug list include Atacand candesartan ; , Avapro irbesartan ; , Benicar olmesartan ; , and.

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A ACCU-CHEK BLOOD GLUCOSE METER ACCU-CHEK TEST STRIPS ACCUNEB ACIPHEX ACTIVELLA ACTOS ACULAR ADVAIR AGENERASE AGRYLIN ALINIA ALLEGRA ALLEGRA-D ALPHAGAN P ALTACE AMARYL AMBIEN ANDROGEL ARICEPT ARIMIDEX AROMASIN ASACOL ASCENSIA TEST STRIPS ASTELIN ATROVENT AVALIDE AVANDAMET AVANDIA AVAPRO AVONEX AZMACORT B BD TEST STRIPS BENICAR BENICAR HCT BETASERON BRAVELLE C CAFERGOT CANASA CARAC CARDIZEM LA CASODEX CEENU CELEBREX CELLCEPT CENESTIN CETROTIDE CIPRODEX CLIMARA CLIMARA PRO COMBIVENT COMBIVIR COMTAN CONCERTA CONDYLOX GEL COPAXONE COPEGUS COREG CORTEF CORTIFOAM COZAAR CREON CRIXIVAN CUPRIMINE CYTOXAN D DAPSONE DEPAKOTE DEPAKOTE ER DEPAKOTE SPRINKLE DETROL DILANTIN DIPENTUM DOSTINEX DOVONEX DUONEB DURAGESIC E EFFEXOR EFFEXOR XR EFUDEX CREAM ELMIRON EMCYT ENTOCORT EC EPINEPHRINE INJECTION EPIVIR EPIVIR-HBV EPZICOM ERGAMISOL ESTRADERM ESTRATEST ESTRATEST HS ETHMOZINE EVISTA EVOXAC EXELON F FARESTON FEMARA FINACEA FLOMAX FLONASE FLOVENT FLOVENT ROTADISK FLOXIN OTIC FORADIL AEROLIZER FORTOVASE FOSAMAX FREESTYLE TEST STRIPS FULVICIN P G FULVICIN U F G GLEEVEC GLUCAGON GLUCO-DEX TEST STRIPS GLUCOSTIX TEST STRIPS H HELIDAC HEPSERA HEXALEN HIVID HYZAAR I IMITREX, all forms INNOPRAN XL INTAL INHALER INTRON A INVIRASE K KALETRA, capsule and solution KEPPRA KYTRIL L LAMICTAL LAMISIL LESCOL LESCOL XL LEUKERAN LEVAQUIN LEVBID LEXAPRO LEXIVA LIDODERM LIPITOR LOPROX TOPICAL CREAM AND GEL LOTEMAX LOVENOX LUMIGAN LYSODREN M MALARONE MAXALT MEPHYTON METADATE CD METADATE ER METHERGINE METROGEL VAGINAL MIACALCIN MIGRANAL MIRAPEX MYLERAN MYLOCEL N NAMENDA NARDIL NASONEX NEUPOGEN NIASPAN NILANDRON NORITATE to be deleted, effective July 31, 2005 ; NORVASC NORVIR NOVOLIN NOVOLOG NOVOLOG MIX 70 30 NUTROPIN NUTROPIN AQ NUTROPIN DEPOT NUVARING O ONE TOUCH GLUCOMETER ONE TOUCH TEST STRIP ORTHO EVRA ORTHO TRI-CYCLEN LO OVIDE OXSORALEN ULTRA OXYCONTIN OXYTROL P PARNATE PEGASYS PEG-INTRON PHOSLO PLAN B PLAVIX PRANDIN PRAVACHOL to be deleted, effective July 31, 2005; alternative is LIPITOR ; * PRECOSE PRED MILD PREDNISONE 1mg PREMARIN PREMARIN CREAM PREMPHASE PREMPRO PREVEN PROCTOFOAM HC PROGRAF PROSCAR PRO VIGIL PULMICORT RESPULES PULMICORT TURBUHALER PULMOZYME Q QUIXIN QVAR R RAPAMUNE REBETRON REBIF REMINYL RENAGEL REQUIP RESCRIPTOR RESTASIS RESTORIL--7.5 mg DOSE ONLY RETIN-A MICRO RETROVIR RHINOCORT AQUA RIDAURA RISPERDAL S SAIZEN SEREVENT SEREVENT DISKUS SEROQUEL SINGULAIR SONATA SPIRIVA. David Stout - GlaxoSmithKline - President Pharmaceuticals Thanks very much, Julian. If you move to the first slide, sales of pharmaceuticals in the third quarter were 4.6 billion pounds, and 2% below last year. Pulling sales down in the quarter was really a combination of the anticipated losses do to the generics for Zofran, Wellbutrin XL, Coreg, along with the unanticipated declines in Avandia, which, combined totaled about 460 million pounds. To give you an update on what's happening with Avandia sales, if you move to the next slide, you'll see here that since the publication of the Nissen article, shares for new RX's and total RX's have declined by slightly more than half with some leveling in the last two months. If you want to see the impact on the sales moving to the next slide, you'll see here the 48% decline in the U.S. sales corresponds to the share loss that we just saw. We're now waiting of course for the final decision on any labelling changes from the FDA. Conversely, though, outside of the U.S., the impact hasn't been as dramatic. In fact, the 11% decline that you see here in Europe is really more impacted by a sales claw back by one of the EU countries. If you actually remove the impact of this accounting adjustment, sales in Europe grew by 4%, which is consistent with the prescription trends and our stable market share. In the International markets, you really have an average of the groups of countries that are more like the U.S., in experiencing a similar situation, and those that are more like the European situation. Now, of course, offsetting all of the generic Zofran, Wellbutrin XL and Coreg impact, part of the Avandia decline is the growth in our key assets. If you move to the next side, you can see that we've picked up just under 400 million pounds in the quarter from some of our other key assets. If you'll move on, you'll see some of this in more detail. I have removed Avandia from the slide for obvious reasons. And I've also taken Coreg off the list, as the initial loss of the IR sales to a generics will be greater than the Coreg CR growth, although I expect that Coreg CR will be added back to the list as we get it more established in the hypertension market. The remaining group of products still contributed over 2 billion pounds and grew 21%. I'll cover off Advair and vaccine in some detail in a moment. Just let me say a few words about some of the others. First, Lamictal growth continues to be driven by the bipolar indication in the U.S. despite generics in Europe. For Valtrex, growth is coming from our indication for reducing the risk of the transmitting genital herpes. Of course, not all surprises are bad ones, I continue to be very pleasantly surprised by Requip's growth, which is being driven by the restless leg syndrome indication. Moving down to Avodart, sales are growing very strong, as is the market growth in the U.S. which was up 17% in the quarter. Our DTC campaign's been very effective with patients and physicians who identify with this shrinking the prostate message. We're also making headway with physicians based on the results of the combat study. And if you'll recall, this is a head-to-head study versus Flomax, which was published in August, and demonstrated superior symptom relief over the long term. Boniva continues to show very strong growth in the U.S., data showing the impact on bone mineral density with once a month Boniva is equivalent to the once weekly Fosamax, which, as you know, itself showed to be better than the bone mineral density impacts over Actinol, and this is helping to drive the growth. And I've, of course, now added Tykerb to the list, which is just getting started but will be a big contributor for many years to come, and on an annualized basis is now running above 0 million a year despite this fairly narrow initial indication, which will expand over time. Now, if we turn to Advair, which of course is our largest product, with third quarter sales were 835 million pounds, with a reported growth of 7%. The U.S. sales reported growth of 5%, but this is below our estimate of the real world growth which was 8%. If.
ABILIFY Accutane * Acebutolol Acetazolamide Acetic Acid HC Otic Acetic Acid Otic Aclovate * ACTIVELLA ACTONEL ACTONEL w CALCIUM ACTONEL WEEKLY ACTOS ACULAR Acyclovir Adalat * ADDERALL XR Adderall * ADVAIR ADVAIR HFA ADVICOR AEROBID-M AGENERASE AGGRENOX AKINETON ALBENZA Albuterol Inhaler Albuterol Nebules Albuterol Tab ALDACTAZIDE 50mg Alesse * ALKERAN Allegra * Allopurinol ALOCRIL ALOMIDE ALPHAGAN P Alprazolam ALTACE ALUPENT MDI Amantadine Amaryl * Ambien * Amcinonide Amiloride Amiloride HCTZ Amino Acid Urea Aminophylline Amiodarone Amitriptyline Amoxicillin Ampicillin ANDRODERM ANTABUSE Anthralin Cream APAP Codeine Arava * ARICEPT ARIMIDEX ARMOUR THYROID B P A ARTHROTEC ASACOL Aspirin Codeine Aspirin 800 CR Aspirin 975 EC ASTELIN Atenolol Atenolol Chlorthal ATRIPLA Atropine Ophth ATROVENT MDI Augmentin * AVALIDE AVANDAMET AVANDARYL AVANDIA AVAPRO AVC AVELOX Aygestin * Azathioprine AZELEX AZMACORT AZOPT AZULFIDINE EC Bacitracin Baclofen Bactrim * BACTROBAN CREAM BACTROBAN NASAL BD PRODUCTS Benazepril Benazepril & HCTZ BENTYL SYRUP BENZACLIN Benzamycin Benzocaine Otic Benzocaine-Antipy-PE Benztropine Betamethasone Betaxolol Bethanechol BETOPTIC-S Biaxin XL * Biaxin * Bicitra * Bisoprolol Bisoprolol HCTZ BLEPHAMIDE OPTH BONIVA 150mg Brontex * Bumetanide Bupropion Bupropion-SR Buspirone Butalbital APAP BYETTA CAFERGOT SUPP CAPITROL B Tier 2 B B Captopril Captopril HCTZ CARAC CARAFATE SUSP Carbachol Ophth Carbamazepine Carbidopa Levodopa Carisoprodol Carisoprodol ASA Carteolol Ophth CASODEX CATAPRES-TTS CEDAX CEENU Cefaclor Cefadroxil Cefpodoxime Tab Cefprozil Ceftin * Celexa * CELLCEPT CENESTIN Cephalexin CERUMENEX CETAPRED Chloral Hydrate Chloramphenicol Ophth Chlordiazepox Clindin Chlordiazepoxide Chloroquine 500mg Chlorothiazide Chlorpromazine Chlorpropamide Chlorthalidone 25mg Chlorthalidone 50mg Chlorzoxazone Cholestyramine Ciclopirox Lotion Cimetidine CIPRO HC CIPRODEX Ciprofloxacin Ciprofloxacin Ophth ; Citalopram CLEOCIN 75mg CAP CLEOCIN PED SOLN CLEOCIN VAG CLIMARA 0.0375mg CLIMARA 0.06mg Climara * Clindamycin Cap Clindamycin Topical Clobetasol Clomipramine Clonazepam Clonidine Clonidine Chlorthal Clorazepate Clotrimazole Troche A M A Clozapine CODEINE SOL TAB CODEINE SOLN Codeine Sulf. Tab. COLAZAL Colchicine Colchicine Probenicid Colestid * COLYMYCIN-S COMBIVENT COMBIVIR CONCERTA Coreg * CORTEF 5mg CORTIFOAM Cortisone CORTISPORIN OPTH. Cortisporin Otic * CORZIDE COSOPT COUMADIN COZAAR CREON CRIXIVAN Cromolyn Neb Cromolyn Ophth CUPRIMINE Cyclobenzaprine 10mg CYCLOGYL 0.5% Cyclopentolate Cyclophosphamide Cyclosporine CYMBALTA Cyproheptadine CYTADREN CYTOMEL CYTOTEC Danazol Dapsone DDAVP TABS Depakene * DEPAKOTE DEPAKOTE ER DEPO-PROVERA 150m DERMASMOOTH Desipramine Desmopressin Desogen * Desonide Desoximetasone DETROL DETROL LA Dexamethasone Dexamethasone Opth Dexedrine * Dextroamphetamine DIAMOX SEQUEL DIASTAT Diazepam A B B. Flamel uses its expertise in polymer chemistry to Flamel Technologies is a world leader in polymerdevelop best-in-class drug delivery technology based drug delivery technology. with established solutions in partnership pharmaceutical and biotechnology partners. Flamel's drug delivery platforms, MEDUSA for proteins and peptides andintellectual property molecules, Flamel's two MICROPUMP for small platforms, allow improved therapeutic characteristics, safety MEDUSA for proteins & peptides and MICROPUMP profiles andmolecules, allow wide varietytherapeutic for small ease of use for a improved of drugs. characteristics, safety profiles, and ease of use for a Flamel's expertise ranges from the lab to the wide variety of drugs. production plant. The FDA-approved manufacturing facility in Pessac now comprises overexpertisesquareBoth platforms are scalable. Flamel's 60, 000 ranges feet. the lab to thefacility is the sole manufacturer of from The Pessac production plant. The FDA-approved microparticles for the in Pessac now comprises manufacturing facility GlaxoSmithKline medicine COREG CR carvedilol phosphate ; Pessac facility is over 100, 000 square-feet. The extended-release capsules. manufacturer of microparticles for the the sole GlaxoSmithKline medicine COREG CR carvedilol Flamel is widely recognizedcapsules. innovation of phosphate ; extended-release for its delivery systems for small molecule and protein drugs, providing tailored its innovation the delivery Flamel is recognized for solutions to of biotech and pharmaceutical industries for either oral or systems for large and small molecules for optimized controlled-release delivery of drugs. Flamelinnovative subcutaneous administration. We provide is turning already-marketed orour biotech and pharmaceutical solutions to enable new drugs into more effective and safer medicines for itself and for its partners. partners to provide optimized controlled-release delivery of drugs. Flamel can improve alreadyThe Companynew drug candidates byin partnership marketed or is dedicated to working applying our with established pharmaceutical and biotechnology technology platforms to solve problems associated companies for the development and commercialization with poor absorption, peak-dose-related side-effects, of productsand can also their pipelines as well as for bioactivity, currently in make them easier to take. new products using Flamel's proprietary delivery systems. This model allows working partnership The Company is dedicated to Flamel toinfocus on its core established pharmaceutical and biotechnology with competency of drug delivery, while leveraging the expertise of itsdevelopment and commercialization companies for the partners. of products currently in their pipelines, as well as for new products using Flamel's proprietary delivery systems. This model allows Flamel to focus on its core competency of drug delivery, while leveraging the expertise of its partners and buy cozaar. Background. Many studies have attempted to identify gastrointestinal stem cells using various methods. To be of value, immunohistochemistry using putative stem cell markers needs to be applicable in routine, formalin fixed paraffin embedded material. Methods. Tissue microarrays TMAs ; were constructed using oesophageal, gastric, ileal and colonic tissues. Brain tissue and tissue from germ cell tumours were used as positive controls. Immunohistochemistry was performed using antibodies against CD133, Musashi-1, Oct-4, Sox-2, Ssea-4, Gpr49 and Dcamlk-1. Results. All antibodies showed expected staining patterns in control tissue. However, none of the antibodies produced a staining pattern consistent with the predicted frequency and location of putative stem cells in the GI tissues. Whilst a variable staining pattern was observed using Oct-4, Sox-2, Ssea-4, Gpr49 and Dcamlk-1, cytoplasmic Musashi-1 staining was restricted to a small subpopulation at the base of ileal and colonic crypts. Additionally, membranous CD133 positivity was seen in a subpopulation of cells at the base of the ileal crypt and in the lower half of the colonic crypts. No distinct staining pattern was observed in gastric or oesophageal tissues for any antibody. Conclusions. This study demonstrates the current problematic nature of immunohistochemical identification of putative gastrointestinal stem cells in FFPE material. Despite appropriately staining controls, none of the markers appeared to stain a putative stem cell population in the correct anatomical location in FFPE GI tissues.
Market sufficiently large for multiple products Coreg carvedilol ; currently a .1 billion product Growing at 30% per year Once-daily formulation expected to enhance use as an antihypertensive High technology hurdle expected to limit number of once-daily carvedilol. Dividend The Board has declared a fourth interim dividend of 14 pence per share, resulting in a dividend for the year of 48 pence per share, a 4 pence increase over the dividend of 44 pence per share for 2005. Cash flow The net cash inflow from operating activities after taxation paid was 4, 357 million, a decrease of 1, 601 million from 2005, arising mainly from the gross taxation payment of .3 billion 1.8 billion ; under the US transfer pricing dispute settlement, partially offset by higher operating profits. Free cash flow was 2.6 billion, a decrease of 44% versus 2005. Free cash flow is the amount of cash generated by the business after meeting its obligations for interest, tax and dividends paid to minority interests, and after capital expenditure on non-current tangible and intangible assets. 2007 outlook Sales growth of existing products and launch of new products are key drivers of GSK's business performance. The sales growth seen from key products such as Seretide Advair, the Avandia group of products, vaccines, Lamictal, Valtrex, Coreg and the rising stars Requip, Avodart and Boniva Bonviva is expected to continue in 2007 although this is likely to be offset by declines in Zofran, Flonase and Wellbutrin due to generic competition. Five major new pharmaceutical product launches are expected in 2007. These include Tykerb, for breast cancer, Cervarix, for cervical cancer in Europe ; , Allermist Avamys, for allergic rhinitis, Coreg CR, for heart conditions, and Trexima, for migraine. GSK's consumer brand portfolio will be strengthened further in 2007, with the launch of 10 products, including alli, a new treatment for weight-loss in the US. Several new products are expected to be filed for approval with the regulatory authorities in 2007, including vaccine opportunities: US filing of Cervarix, Rotarix, for rotavirus, and the European filing of Synflorix, a vaccine against meningitis, pneumonia and otitis. GSK continues to progress the development of vaccines for use before, and in the event of, a flu pandemic. In January 2007, GSK submitted its H5N1 vaccine to European regulators for approval for prepandemic use. GSK now has 31 major product opportunities in phase III development or registration, comprising 13 new chemical entities NCEs ; , 6 new vaccines and 12 product line extensions PLEs ; . GSK's published earnings guidance for 2007 is that earnings per share growth is expected to be 8% to 10% in CER terms. Statements regarding the prospects for COREG CR. 4. On August 23, 2007, Associated Press published an article entitled "Flamel. The issuance of securities. As a company, Alkermes had operated at a net-operating loss since being founded in 1987. As of March 31, 2002, Alkermes' accumulated deficit was 3.9 million. For the years 1999, 2000, 2001 and 2002, Alkermes had cash, cash equivalents and short-term investments of 3, 419, 7, 367, 4, 928 and 2, 347, respectively. Alkermes operated at approximately a million deficit each quarter. On February 16, 2000, Alkermes announced the private placement of 0 million aggregate principal amount of its 3-3 4 % convertible subordinated notes due 2007. This transaction closed on February 18, 2000. The offering was made through initial purchasers to qualified institutional buyers, and raised desperately- needed cash for Alkermes. News of this badlyneeded financing sent shares soaring nearly 90% in value in the days following the announcement. 43. Defendants were further motivated to inflate their stock price because of their own. 210 ; 1165784 220 ; 28 March 2007 730 ; Cosmeceutical Pty Ltd ACN ARBN 110 020 945 of 307 Lord Street HIGHGATE WA 6003, AUSTRALIA AU ; . 750 ; Cosmeceutical Pty Ltd 307 Lord Street HIGHGATE WA 6003 511 ; 510 ; Cl. 3 Beauty products; non-medicated skin care beauty products 540.
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If patients stop taking COREG CR or COREG suddenly, they could have chest pain and or a heart attack. If the doctor decides that a patient should stop taking COREG CR or COREG, the doctor may slowly lower the dose over a period of time before stopping it completely. Some common side effects associated with COREG CR and COREG include shortness of breath, a slow heartbeat, weight gain, fatigue, hypotension, dizziness, faintness, or runny nose sore throat. People taking COREG CR or COREG who have any of these symptoms should call their doctor. Additionally, if patients experience fatigue or dizziness, they should sit or lie down and avoid driving or hazardous tasks. Beta-blockers may mask the symptoms of an overactive thyroid or low blood sugar, or may alter blood sugar levels. People with diabetes should report any changes in blood sugar levels to their physician.
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Beta blockers-usually contraindicated due to reducing cardiaccontractility, but coreg and toprol xl improve cardiac performance in somepatients.
This decrease in the price of Flamel's ADRs price was a result of the artificial inflation caused by defendants' misleading statements coming out of the ADRs. 22. Under Fire": There's no sector more volatile than the pharma sector as Flamel Technologies has proven in the past three months. Shares of the tiny drug developer have fallen 65% since the beginning of June and were down more yesterday after unfavorable data was released on its lead drug, heart failure treatment Coreg CR. * * * On August 24, 2007, Motley Fool reported the following in an article entitled "Flamel.

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The adjustment for share-based payments is expected to reduce to a more normal level of 200-250 million by 2005. The considerably higher charge in 2004 and 2003 arises from two main factors. Relatively few share options were granted during 2000 when the GW SB merger was being finalised, but then in 2001 there was a full "catch-up" grant early in the year followed by the normal annual grant in November 2001. In addition, the grants in 2001 were made at an average share price in excess of 18. These share options will become exercisable in 2004 and therefore fall out of the charge in 2005, when the charge will reflect more current share prices and more normal grant levels. Coreg capitalisation and amortisation The North American rights to Coreg were acquired at the time of the GW SB merger as partial consideration for the required disposal of Kytril to Roche. Under UK GAAP this was accounted for as an exchange of assets with no value being attributed to Coreg on the balance sheet. IFRS, however, requires the acquired rights to Coreg to be added to intangible assets at their fair value on the date of acquisition of 0 million, and then amortised over their remaining useful life of eight years. This adjustment reduces 2004 profit before tax by 27 million 2003 31 million ; and EPS by 0.3 pence 2003 0.3 pence ; . Other intangible assets amortisation Under UK GAAP, GlaxoSmithKline amortises intangible assets over their estimated expected useful lives from acquisition, which can be up to maximum of 15 years. IFRS only permits amortisation to commence when the asset becomes available for use, with annual impairment testing required before this point. GlaxoSmithKline has determined that the point at which amortisation of product-related assets commences under IFRS will normally be regulatory approval. The majority of GlaxoSmithKline's intangible assets relates to the acquisition of rights to compounds in development and so has not reached the point at which amortisation commences. This has led to a reduction in the amortisation charge in the periods presented, which is likely to reverse in the future as these compounds reach regulatory approval and amortisation is then charged over a shorter period. Profit before tax in 2004 increases by 43 million 2003 43 million ; and EPS by 0.5 pence 2003 0.5 pence ; . Goodwill amortisation UK GAAP requires goodwill to be amortised over its estimated expected useful life, which GlaxoSmithKline has determined to be normally no longer than 20 years. Under IFRS, however, goodwill is considered to have an indefinite life and so is not amortised, but is subject to annual impairment testing. This adjustment therefore reverses the goodwill amortisation charged under UK GAAP, including that recorded in the profit on share of associates line relating to the acquisition of the Group's interest in Quest Diagnostics Inc. Under the business combinations exemption of IFRS 1, goodwill previously written off direct to reserves under UK GAAP is not recycled to the income statement on the disposal or part-disposal of the subsidiary or associate, as it would be under UK GAAP. The adjustment increases 2004 profit before tax by 38 million 2003 26 million ; and EPS by 0.7 pence 2003 0.4 pence.

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Search date: March 26, 2006 Databases searched: OVID Medline, In Process and Other Non-Indexed Citations, Embase, Cochrane Library, INAHTA Database: Ovid MEDLINE R ; 1996 to March Week 3 2006 Search Strategy: exp Electric Stimulation Therapy 9928 ; 2 exp Gastroparesis 402 ; 3 exp gastrointestinal motility or exp gastric emptying 7717 ; 4 exp Obesity, Morbid 3003 ; 5 or 2-4 10857 ; 6 1 and 5 118 ; 7 gastric adj1 stimulat$ ; .mp. [mp title, original title, abstract, name of substance word, subject heading word] 356 ; 8 5 and 7 90 ; 9 stomach or duodenal or intestinal or gastric ; adj1 electric$ stimula$ or pacer$ or pacing or pacemaker .mp. [mp title, original title, abstract, name of substance word, subject heading word] 147 ; 10 enterra$.mp. 2 ; 11 gastroelectric$ or gastro-electric$ ; adj1 stimulat$ or pacer$ or pacing or pacemaker .mp. [mp title, original title, abstract, name of substance word, subject heading word] 0 ; 12 6 278 ; 13 limit 12 to humans and english language and yr "2000 - 2006" ; 116 ; 14 systematic review$ or meta-analysis or metaanalysis ; .mp. [mp title, original title, abstract, name of substance word, subject heading word] 22571 ; 15 13 and 14 2 ; 16 116 ; 17 limit 16 to case reports or comment or editorial or letter or "review" ; 46 ; 18 16 not 17 70 ; 19 Database: EMBASE 1980 to 2006 Week 12 Search Strategy: exp Electrostimulation 24245 ; 2 exp Stomach Paresis 1089 ; 3 exp Stomach Emptying 6777 ; 4 exp Stomach Motility 2874 ; 5 exp Morbid Obesity 2782 ; 6 or 2-5 12105 ; 7 1 and 6 143 ; 8 gastric adj1 stimulat$ ; .mp. [mp title, abstract, subject headings, heading word, drug trade name, original title, device manufacturer, drug manufacturer name] 1799 ; 9 6 and 8 211 ; 10 7 or 333.

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